Liposaccharide metabolic process

Across TCGA cell cohorts, RNA activity of the Liposaccharide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOXN3, IFNW1, and H2BC12, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FOXN3 grouped by Liposaccharide metabolic process-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	FOXN3 →	-1.737	-1.909	.008	<.001	3	4
LUNG_SCLC	IFNW1 →	+0.025	+0.648	.004	.005	3	3
LARGE_INTESTINE	H2BC12 →	-1.454	-0.914	.004	.004	3	3
LARGE_INTESTINE	H3C10 →	-0.844	-0.826	.008	.008	3	3
LUNG_NSCLC_LUAD	GLO1 →	-0.634	-0.581	<.001	.004	3	3
UPPER_AERODIGESTIVE_TRACT	ULBP3 →	-0.947	-1.023	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FOXN3 by Liposaccharide metabolic process activity — URINARY_TRACT

Explore this box plot interactively →