Liposaccharide metabolic process

Across TCGA cell cohorts, RNA activity of the Liposaccharide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HEXA, LAMP1, and HM13, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Liposaccharide metabolic process activity versus HEXA in BLOOD_Leukemia (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HEXA →	+0.531	+0.801	.001	.004	3	7
LUNG_SCLC	LAMP1 →	+1.207	+1.246	.002	.002	3	6
KIDNEY	HM13 →	+1.360	+0.285	.001	.002	3	5
LIVER	ANP32A →	-0.910	-0.397	.001	.008	3	5
BLOOD_Leukemia	FNDC3B →	+1.463	+1.107	.002	.001	3	5
LUNG_SCLC	CD164 →	+1.255	+1.154	.005	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903509 vs HEXA — BLOOD_Leukemia

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