Negative regulation of brown fat cell differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of brown fat cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRPV4, GATA2, and GATA2-AS1, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of brown fat cell differentiation activity versus TRPV4 in CHOL (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	TRPV4 →	+2.234	+0.081	<.001	<.001	3	29
UCS	GATA2 →	+1.915	+0.118	<.001	<.001	2	28
UCS	GATA2-AS1 →	+1.931	+0.108	<.001	.002	3	23
ESCA	MIR128-1 →	-0.346	-0.101	<.001	<.001	3	22
THYM	FLCN →	+0.586	+0.056	.001	<.001	3	19
CHOL	ZNF469 →	+1.976	+0.126	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903444 vs TRPV4 — CHOL

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