Negative regulation of brown fat cell differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of brown fat cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PIAS1, TNKS1BP1_S1715, and UBN1_S660, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of brown fat cell differentiation activity versus PIAS1 in GBM (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PIAS1 →	-0.349	-0.841	<.001	<.001	3	3
UCEC	TNKS1BP1_S1715 →	-0.599	-0.448	<.001	<.001	3	3
PDAC	UBN1_S660 →	-0.689	-0.417	.002	.003	3	3
GBM	MICALL1_S588 →	-0.490	-0.941	.001	.003	3	3
LSCC	RFFL →	+0.265	+0.883	<.001	<.001	3	2
GBM	SESN1_S314 →	-0.749	-1.094	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903444 vs PIAS1 — GBM

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