Negative regulation of brown fat cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of brown fat cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MED1, TSPAN15, and PPIE, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MED1 grouped by Negative regulation of brown fat cell differentiation-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MED1 →	-0.451	-0.162	.004	.003	2	6
SKIN	TSPAN15 →	-0.233	-0.155	.008	<.001	3	4
BLOOD_Myeloma	PPIE →	-0.368	-0.194	.002	.002	3	4
LARGE_INTESTINE	ITPK1 →	+0.145	+0.171	.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	RAD9B →	+0.199	+0.168	.003	.001	2	5
CNS	DHX8 →	-0.303	-0.108	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MED1 by Negative regulation of brown fat cell differentiation activity — BLOOD_Myeloma

Explore this box plot interactively →