Positive regulation of cell maturation

Across TCGA patient cohorts, RNA activity of the Positive regulation of cell maturation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VGLL3, AMMECR1, and STARD3NL, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell maturation activity versus VGLL3 in BRCA (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	VGLL3 →	-0.677	-0.700	<.001	<.001	3	3
BRCA	AMMECR1 →	-0.498	-0.630	<.001	<.001	3	2
BRCA	STARD3NL →	-0.293	-0.693	<.001	<.001	3	2
OV	RPS16 →	+0.678	+0.540	.003	.006	3	2
BRCA	FBL →	+0.786	+0.774	<.001	.001	3	2
BRCA	AHR →	-0.805	-0.966	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903431 vs VGLL3 — BRCA

Explore this scatter interactively →