Positive regulation of cell maturation

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell maturation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USP9Y, GOLGA6L9, and CCDC74A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, USP9Y grouped by Positive regulation of cell maturation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	USP9Y →	-1.548	-0.683	<.001	.007	3	5
OESOPHAGUS	GOLGA6L9 →	-0.830	-1.137	.003	.006	3	5
BONE	CCDC74A →	-2.291	-1.239	.002	.002	3	4
BONE	FAM163B →	-0.718	-1.289	.001	.001	3	4
LARGE_INTESTINE	ZNF669 →	+0.662	+1.207	.005	<.001	3	4
SKIN	LCAT →	-0.710	-0.799	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

USP9Y by Positive regulation of cell maturation activity — SKIN

Explore this box plot interactively →