Negative regulation of cell maturation

Across TCGA patient cohorts, RNA activity of the Negative regulation of cell maturation pathway is significantly associated with the RNA expression of multiple genes, with the ESCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBX6, NPR2, and EDNRB, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell maturation activity versus TBX6 in ESCA (Pearson r = 0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	TBX6 →	+0.693	+0.050	<.001	<.001	3	19
ACC	NPR2 →	+1.373	+0.061	<.001	<.001	3	18
TGCT	EDNRB →	+1.233	+0.062	<.001	<.001	3	17
TGCT	BCL11A →	+1.294	+0.082	<.001	<.001	3	14
SCLC	LILRB4 →	-1.331	-0.762	.002	.001	1	15
LGG	LINC01094 →	-0.666	-0.029	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903430 vs TBX6 — ESCA

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