Negative regulation of cell maturation

Across TCGA patient cohorts, RNA activity of the Negative regulation of cell maturation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SETP10, RPRD2, and ZNRF3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell maturation activity versus SETP10 in HNSC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SETP10 →	+0.659	+0.401	<.001	.004	3	6
HNSC	RPRD2 →	+0.788	+0.580	<.001	<.001	3	6
COAD	ZNRF3 →	+0.778	+0.282	.001	.007	3	5
LSCC	PLAGL2 →	+0.517	+0.693	<.001	<.001	3	5
HNSC	MAP3K21 →	+1.158	+0.473	<.001	<.001	3	5
LSCC	CDK12 →	+0.554	+0.962	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903430 vs SETP10 — HNSC

Explore this scatter interactively →