Regulation of cell maturation

Across TCGA patient cohorts, RNA activity of the Regulation of cell maturation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNKS1BP1_S369, KIFBP, and MAGED2_T72, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell maturation activity versus TNKS1BP1_S369 in GBM (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TNKS1BP1_S369 →	+0.567	+0.103	.002	<.001	3	4
PDAC	KIFBP →	+0.235	+0.063	<.001	<.001	3	4
BRCA	MAGED2_T72 →	+0.647	+0.031	<.001	.003	3	4
LUAD	LARP4 →	+0.291	+0.055	<.001	<.001	3	4
HNSC	CALCOCO2 →	+0.263	+0.049	.004	.009	3	4
BRCA	DTX3L_S539 →	+0.485	+0.049	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903429 vs TNKS1BP1_S369 — GBM

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