Regulation of cell maturation

Across TCGA cell cohorts, RNA activity of the Regulation of cell maturation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMOX1, CDCA7L, and GALT, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HMOX1 grouped by Regulation of cell maturation-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	HMOX1 →	-2.441	-1.315	.003	.004	3	5
OVARY	CDCA7L →	+2.289	+1.259	.002	<.001	3	4
LUNG_NSCLC_LUSC	GALT →	-0.904	-1.311	.004	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	HDHD3 →	-1.044	-1.293	.003	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	SLC35D2 →	-0.627	-1.202	.009	.001	3	3
UPPER_AERODIGESTIVE_TRACT	ZC3H3 →	-0.518	-1.212	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HMOX1 by Regulation of cell maturation activity — OESOPHAGUS

Explore this box plot interactively →