Regulation of cell maturation

Across TCGA cell cohorts, RNA activity of the Regulation of cell maturation pathway is significantly associated with the drug response of multiple features, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are AZD5153, YK-4-279, and XAV939, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AZD5153 grouped by Regulation of cell maturation-low versus -high activity in LUNG_SCLC.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	AZD5153 →	-1.451	-0.409	.007	.002	3	2
BLOOD_Leukemia	YK-4-279 →	+0.652	+0.414	.008	.013	3	1
BLOOD_Leukemia	XAV939 →	+0.446	+0.453	.007	.002	3	1
BLOOD_Leukemia	Ponatinib →	+1.599	+0.328	.020	.039	3	1
BLOOD_Leukemia	RVX-208 →	+0.590	+0.733	.002	.047	3	1
BLOOD_Leukemia	765771 →	-0.620	-0.408	<.001	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AZD5153 by Regulation of cell maturation activity — LUNG_SCLC

Explore this box plot interactively →