Negative regulation of reactive oxygen species biosynthetic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of reactive oxygen species biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDX18, EMX2, and DDX50, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of reactive oxygen species biosynthetic process activity versus DDX18 in OV (Pearson r = -0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DDX18 →	-0.496	-0.155	.001	<.001	3	4
PDAC	EMX2 →	-0.196	-0.149	<.001	<.001	3	4
BRCA	DDX50 →	-0.354	-0.081	.006	.005	3	3
BRCA	THUMPD2 →	-0.270	-0.073	.002	.003	3	3
BRCA	HNRNPA1L2 →	-0.543	-0.089	.009	.009	3	3
BRCA	RPL3P6 →	-0.977	-0.088	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903427 vs DDX18 — OV

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