Negative regulation of reactive oxygen species biosynthetic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of reactive oxygen species biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HNRNPA1, LUC7L, and MRPS31, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of reactive oxygen species biosynthetic process activity versus HNRNPA1 in LUNG_SCLC (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	HNRNPA1 →	+0.441	+0.126	.006	.007	3	8
PANCREAS	LUC7L →	+0.830	+0.205	.007	.001	3	6
OESOPHAGUS	MRPS31 →	+0.677	+0.177	.006	.004	3	6
OVARY	EEF2 →	+0.826	+0.174	.003	.006	3	6
URINARY_TRACT	NTHL1 →	+1.000	+0.351	<.001	.005	2	7
BLOOD_Lymphoma	PLEKHN1 →	-1.053	-0.089	.009	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903427 vs HNRNPA1 — LUNG_SCLC

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