Regulation of reactive oxygen species biosynthetic process

Across TCGA patient cohorts, RNA activity of the Regulation of reactive oxygen species biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARHGAP25_S363, RCSD1_S68, and SAMSN1_S23, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of reactive oxygen species biosynthetic process activity versus ARHGAP25_S363 in LSCC (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ARHGAP25_S363 →	+0.459	+0.032	.005	.003	3	7
GBM	RCSD1_S68 →	+0.354	+0.036	<.001	.002	3	5
OV	SAMSN1_S23 →	+0.524	+0.041	.003	.005	3	5
GBM	SF3B3 →	-0.258	-0.056	<.001	<.001	3	5
GBM	SF3B6 →	-0.266	-0.057	<.001	<.001	3	5
PDAC	SSH1_S576 →	+0.505	+0.035	.005	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903426 vs ARHGAP25_S363 — LSCC

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