Regulation of reactive oxygen species biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of reactive oxygen species biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGEF37, ZNF491, and BTBD11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARHGEF37 grouped by Regulation of reactive oxygen species biosynthetic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ARHGEF37 →	-1.167	-0.178	.003	.008	3	4
URINARY_TRACT	ZNF491 →	-0.618	-0.205	<.001	<.001	3	4
OESOPHAGUS	BTBD11 →	-1.351	-0.180	.002	.005	3	3
BREAST	C12orf73 →	-0.532	-0.260	<.001	.008	3	3
BLOOD_Myeloma	HTATIP2 →	+1.116	+0.218	.006	.006	3	3
BLOOD_Myeloma	IL12A →	-1.356	-0.216	.005	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARHGEF37 by Regulation of reactive oxygen species biosynthetic process activity — SKIN

Explore this box plot interactively →