Regulation of reactive oxygen species biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of reactive oxygen species biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SERPINB8, SYF2, and NMD3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of reactive oxygen species biosynthetic process activity versus SERPINB8 in BREAST (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SERPINB8 →	+1.275	+0.212	<.001	<.001	3	5
KIDNEY	SYF2 →	+0.560	+0.155	.008	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	NMD3 →	+0.724	+0.205	.004	<.001	3	5
SKIN	CLCN7 →	+1.221	+0.200	.001	<.001	3	4
LIVER	ZBTB7A →	+0.830	+0.237	.002	<.001	3	4
STOMACH	ARRB2 →	+1.156	+0.248	.009	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903426 vs SERPINB8 — BREAST

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