Positive regulation of synaptic vesicle recycling

Across TCGA patient cohorts, RNA activity of the Positive regulation of synaptic vesicle recycling pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNE1_S460, SYNE1_S8305, and CYFIP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of synaptic vesicle recycling activity versus SYNE1_S460 in LSCC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SYNE1_S460 →	+0.618	+0.073	.001	<.001	3	6
LSCC	SYNE1_S8305 →	+0.618	+0.073	.001	<.001	3	6
GBM	CYFIP2 →	+0.395	+0.080	<.001	.002	3	6
UCEC	RENBP →	+0.638	+0.086	<.001	<.001	3	5
UCEC	WIPF1 →	+0.404	+0.107	.001	.001	3	5
LSCC	EVL →	+0.390	+0.081	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903423 vs SYNE1_S460 — LSCC

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