Positive regulation of synaptic vesicle recycling

Across TCGA patient cohorts, RNA activity of the Positive regulation of synaptic vesicle recycling pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC141, LMNB2, and BTLA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of synaptic vesicle recycling activity versus CCDC141 in LSCC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CCDC141 →	+0.855	+0.999	<.001	<.001	3	4
LSCC	LMNB2 →	-0.596	-0.672	.003	.003	3	4
LSCC	BTLA →	+0.698	+0.707	.001	.002	3	4
GBM	TARS1 →	-0.223	-0.132	.006	.002	3	4
UCEC	CCL14 →	+0.510	+0.605	.003	.003	3	4
LSCC	CD69 →	+1.063	+1.019	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903423 vs CCDC141 — LSCC

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