Positive regulation of synaptic vesicle recycling

Across TCGA cell cohorts, RNA activity of the Positive regulation of synaptic vesicle recycling pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNHG32, STARD9, and CDK18, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SNHG32 grouped by Positive regulation of synaptic vesicle recycling-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SNHG32 →	-0.904	-0.449	.005	.001	3	5
BLOOD_Myeloma	STARD9 →	-1.547	-0.377	.007	.004	3	4
PANCREAS	CDK18 →	-1.304	-0.283	.003	<.001	3	3
LUNG_SCLC	COX6B1 →	+0.537	+0.301	.008	.002	3	3
LUNG_SCLC	POLG2 →	+0.459	+0.210	<.001	.002	3	3
LUNG_SCLC	ZMPSTE24 →	+1.017	+0.207	.009	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SNHG32 by Positive regulation of synaptic vesicle recycling activity — BLOOD_Lymphoma

Explore this box plot interactively →