Positive regulation of synaptic vesicle recycling

Across TCGA cell cohorts, RNA activity of the Positive regulation of synaptic vesicle recycling pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DSE, COL12A1, and EEF1B2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of synaptic vesicle recycling activity versus DSE in URINARY_TRACT (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	DSE →	+1.538	+1.205	.004	.004	3	6
LUNG_NSCLC_LUSC	COL12A1 →	+3.741	+1.474	.001	<.001	3	5
LIVER	EEF1B2 →	-0.927	-1.028	<.001	.005	3	5
LUNG_SCLC	FER →	+1.125	+1.235	.001	<.001	3	5
LUNG_SCLC	MARS2 →	-1.073	-1.182	.004	<.001	3	5
PANCREAS	GLYCTK →	-1.664	-1.486	.007	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903423 vs DSE — URINARY_TRACT

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