Regulation of adherens junction organization

Across TCGA patient cohorts, RNA activity of the Regulation of adherens junction organization pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FLT1, AUH, and PCK2_S304, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of adherens junction organization activity versus FLT1 in OV (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FLT1 →	+0.520	+0.097	<.001	<.001	3	4
HNSC	AUH →	+0.274	+0.062	.008	.003	3	4
HNSC	PCK2_S304 →	+0.425	+0.052	<.001	.002	3	4
LUAD	ALKBH5_S64 →	+0.456	+0.058	.002	.002	3	4
LUAD	RTN1_S166 →	-0.458	-0.069	.001	<.001	3	4
LUAD	SLC27A2 →	+0.634	+0.067	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903391 vs FLT1 — OV

Explore this scatter interactively →