Regulation of adherens junction organization

Across TCGA patient cohorts, RNA activity of the Regulation of adherens junction organization pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are E2F1, SNF8, and FIGNL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of adherens junction organization activity versus E2F1 in BRCA (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	E2F1 →	-0.747	-0.197	.002	.001	3	5
LSCC	SNF8 →	-0.248	-0.136	.009	.001	3	5
PDAC	FIGNL1 →	-0.371	-0.130	.004	.006	3	5
LUAD	BYSL →	-0.496	-0.202	<.001	<.001	3	4
LSCC	GRHL1 →	-0.829	-0.196	.003	.003	3	4
PDAC	MRAP2 →	+0.989	+0.141	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903391 vs E2F1 — BRCA

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