Regulation of adherens junction organization

Across TCGA cell cohorts, RNA activity of the Regulation of adherens junction organization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF3, PROS1, and PKDCC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF3 grouped by Regulation of adherens junction organization-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ZNF3 →	-0.536	-0.605	.006	.007	2	5
LUNG_SCLC	PROS1 →	-2.732	-0.287	.003	<.001	3	4
OVARY	PKDCC →	-1.778	-0.576	.004	.002	2	4
SKIN	GID8 →	+0.404	+0.672	<.001	.009	3	3
SKIN	PTCD2 →	+0.389	+0.828	.001	.001	3	3
OVARY	RTL8C →	-0.618	-0.516	.003	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF3 by Regulation of adherens junction organization activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →