Regulation of homophilic cell adhesion

Across TCGA patient cohorts, RNA activity of the Regulation of homophilic cell adhesion pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SGCD, TLN2, and MMP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of homophilic cell adhesion activity versus SGCD in BRCA (Pearson r = -0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SGCD →	+0.473	+0.048	.002	.001	3	5
LSCC	TLN2 →	+0.430	+0.076	<.001	<.001	3	5
LSCC	MMP2 →	+0.588	+0.065	<.001	.001	3	5
BRCA	MSRB3 →	+0.601	+0.057	<.001	<.001	3	5
LSCC	SEPTIN2 →	+0.142	+0.064	<.001	<.001	3	5
LSCC	PLS3_S293 →	+0.540	+0.092	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903385 vs SGCD — BRCA

Explore this scatter interactively →