Regulation of homophilic cell adhesion

Across TCGA cell cohorts, RNA activity of the Regulation of homophilic cell adhesion pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HAUS2, NMD3, and NUP188, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of homophilic cell adhesion activity versus HAUS2 in LARGE_INTESTINE (Pearson r = -0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HAUS2 →	-1.116	-2.091	.005	<.001	3	2
LARGE_INTESTINE	NMD3 →	-0.926	-2.018	.001	<.001	3	2
LARGE_INTESTINE	NUP188 →	-0.990	-1.906	.003	<.001	3	2
LARGE_INTESTINE	CENPM →	-0.976	-1.947	.004	<.001	3	1
LARGE_INTESTINE	SLC25A17 →	-1.212	-1.568	.005	.005	3	1
LARGE_INTESTINE	CD9 →	+1.123	+1.342	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903385 vs HAUS2 — LARGE_INTESTINE

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