Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FZD1, VCL_S795, and DOCK7, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway activity versus FZD1 in OV (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FZD1 →	+0.730	+0.045	<.001	<.001	3	7
BRCA	VCL_S795 →	+0.571	+0.057	<.001	<.001	3	6
HNSC	DOCK7 →	+0.253	+0.077	.002	.007	3	6
OV	GOLIM4 →	+0.375	+0.037	.004	.005	3	6
BRCA	CRTAP →	+0.709	+0.068	<.001	<.001	3	6
LSCC	FKBP14 →	+0.503	+0.079	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903377 vs FZD1 — OV

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