Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TENM4, BMP7, and PLCD3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway activity versus TENM4 in GBM (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TENM4 →	+0.564	+0.122	.003	.002	3	4
PDAC	BMP7 →	+0.684	+0.102	.005	.004	3	4
GBM	PLCD3 →	+0.537	+0.160	<.001	<.001	3	3
BRCA	GAS2L1 →	+0.596	+0.124	.003	.004	3	3
COAD	FGR →	-0.640	-0.093	.004	.005	3	3
HNSC	MEGF6 →	+0.659	+0.145	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903377 vs TENM4 — GBM

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