Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATF4, CTNNB1, and PARK7, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATF4 grouped by Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ATF4 →	-0.341	-0.793	<.001	.007	3	10
LARGE_INTESTINE	CTNNB1 →	-1.870	-0.901	<.001	.001	3	7
CNS	PARK7 →	-0.306	-1.084	.002	.007	3	5
BLOOD_Leukemia	FZD1 →	-0.292	-0.815	<.001	.002	2	5
LIVER	DCAF4 →	+0.153	+1.081	<.001	.004	3	4
LARGE_INTESTINE	UBFD1 →	-0.102	-0.468	.006	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATF4 by Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway activity — UPPER_AERODIGESTIVE_TRACT

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