Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLEKHG4, LGALS1, and MYCL, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLEKHG4 grouped by Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PLEKHG4 →	-2.495	-1.460	.004	.002	2	6
LARGE_INTESTINE	LGALS1 →	-3.113	-0.721	.001	.009	3	4
LARGE_INTESTINE	MYCL →	+1.688	+0.614	<.001	.008	3	4
LARGE_INTESTINE	PPP1R18 →	-1.815	-0.618	<.001	.006	3	4
BLOOD_Leukemia	PTGS1 →	-2.287	-0.856	.007	.007	3	4
STOMACH	RNF43 →	+3.947	+1.035	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLEKHG4 by Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway activity — SOFT_TISSUE

Explore this box plot interactively →