Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FASTKD1, ZNF709, and ZNF281, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FASTKD1 grouped by Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	FASTKD1 →	+0.243	+0.100	.006	.002	3	5
BLOOD_Leukemia	ZNF709 →	+0.278	+0.186	.004	.001	3	5
SOFT_TISSUE	ZNF281 →	-0.145	-0.157	.006	.001	3	5
LUNG_NSCLC_LUAD	CABIN1 →	+0.165	+0.108	.003	.001	3	4
BREAST	FUT9 →	+0.217	+0.076	<.001	.005	3	4
OESOPHAGUS	AHI1 →	-0.252	-0.129	.007	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FASTKD1 by Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway activity — OESOPHAGUS

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