Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KDF1, CDS1, and SLC2A9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway activity versus KDF1 in OVARY (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	KDF1 →	+2.237	+0.216	<.001	.001	3	6
LUNG_NSCLC_LUAD	CDS1 →	+1.927	+0.239	<.001	.002	3	6
STOMACH	SLC2A9 →	+1.652	+0.341	.005	.001	3	5
STOMACH	CRB3 →	+3.606	+0.258	.001	.001	3	5
STOMACH	MPZL3 →	+2.271	+0.378	<.001	<.001	2	6
LUNG_NSCLC_LUAD	SOWAHB →	+1.845	+0.297	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903377 vs KDF1 — OVARY

Explore this scatter interactively →