Positive regulation of fear response

Across TCGA patient cohorts, RNA activity of the Positive regulation of fear response pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPP2R5A_S41, NELFCD, and EEF1A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of fear response activity versus PPP2R5A_S41 in CCRCC (Pearson r = -0.55).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PPP2R5A_S41 →	-0.767	-0.119	<.001	.001	3	5
OV	NELFCD →	-0.291	-0.068	.002	.004	3	5
HNSC	EEF1A1 →	+0.257	+0.098	<.001	.009	3	4
HNSC	PPP1R3G_S86 →	+1.339	+0.074	<.001	.001	3	4
BRCA	GJA1 →	+0.596	+0.042	.003	.003	3	4
LUAD	RIPOR2_S37 →	-0.510	-0.059	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903367 vs PPP2R5A_S41 — CCRCC

Explore this scatter interactively →