Positive regulation of fear response

Across TCGA patient cohorts, RNA activity of the Positive regulation of fear response pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM179B, TTK, and KIF2C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of fear response activity versus TMEM179B in BRCA (Pearson r = -0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TMEM179B →	-0.294	-0.132	.005	.003	3	5
LSCC	TTK →	-0.558	-0.294	.001	<.001	3	5
LSCC	KIF2C →	-0.431	-0.243	.002	.005	3	5
LSCC	IPCEF1 →	+0.338	+0.256	.008	.003	3	5
BRCA	CORO2A →	-0.704	-0.148	.004	.002	3	4
BRCA	TFIP11 →	-0.387	-0.181	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903367 vs TMEM179B — BRCA

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