Positive regulation of fear response

Across TCGA patient cohorts, RNA activity of the Positive regulation of fear response pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MEF2C_S222, MEF2C, and NES_S768, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of fear response activity versus MEF2C_S222 in HNSC (Pearson r = 0.64).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MEF2C_S222 →	+1.039	+0.632	<.001	<.001	3	5
LSCC	MEF2C →	+0.512	+0.458	<.001	<.001	3	4
HNSC	NES_S768 →	+1.098	+0.638	<.001	.001	3	4
HNSC	SYNPO_S685 →	+0.650	+0.493	<.001	<.001	3	4
HNSC	TXNDC5 →	+0.837	+0.404	<.001	<.001	3	4
HNSC	CELF2 →	+0.696	+0.444	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903367 vs MEF2C_S222 — HNSC

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