Positive regulation of fear response

Across TCGA cell cohorts, RNA activity of the Positive regulation of fear response pathway is significantly associated with the drug response of multiple features, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Afatinib, SB590885, and Tamoxifen, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Afatinib grouped by Positive regulation of fear response-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Afatinib →	-0.200	-1.644	.035	<.001	3	1
BLOOD_Lymphoma	SB590885 →	-0.846	-1.644	.002	<.001	3	1
BLOOD_Lymphoma	Tamoxifen →	-0.579	-1.644	.028	<.001	3	1
BLOOD_Lymphoma	AZD6094 →	+0.156	+1.644	.036	<.001	3	1
BLOOD_Lymphoma	JAK3_7406 →	+0.510	+1.644	.041	<.001	3	1
BLOOD_Lymphoma	Nelarabine →	+0.283	+1.644	.035	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Afatinib by Positive regulation of fear response activity — BLOOD_Lymphoma

Explore this box plot interactively →