Regulation of fear response

Across TCGA patient cohorts, RNA activity of the Regulation of fear response pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD40LG, CD79A, and POLD2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of fear response activity versus CD40LG in LSCC (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CD40LG →	+0.651	+0.816	<.001	<.001	3	4
LSCC	CD79A →	+1.193	+0.834	<.001	<.001	3	4
LSCC	POLD2 →	-0.499	-0.585	<.001	.003	3	4
HNSC	KLRB1 →	+0.602	+0.838	.007	.001	3	4
HNSC	MAPK13 →	-0.605	-0.797	<.001	<.001	3	4
LSCC	UBQLN4 →	-0.608	-0.667	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903365 vs CD40LG — LSCC

Explore this scatter interactively →