Regulation of fear response

Across TCGA cell cohorts, RNA activity of the Regulation of fear response pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPRJ, MEIS3, and LSR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTPRJ grouped by Regulation of fear response-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PTPRJ →	-2.063	-1.218	.002	.007	3	5
KIDNEY	MEIS3 →	-2.511	-1.142	<.001	.002	3	4
LUNG_NSCLC_LUSC	LSR →	+3.435	+1.689	.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	GLT8D1 →	-0.957	-0.976	.001	<.001	3	4
LUNG_NSCLC_LUSC	RUSC2 →	-1.641	-1.656	.001	<.001	3	4
LUNG_NSCLC_LUSC	AHRR →	-2.553	-1.303	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTPRJ by Regulation of fear response activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →