Regulation of fear response

Across TCGA cell cohorts, RNA activity of the Regulation of fear response pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSPH, ADAT3, and SAMD9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of fear response activity versus PSPH in CNS (Pearson r = -0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PSPH →	-1.225	-1.511	.004	.004	3	4
SOFT_TISSUE	ADAT3 →	+2.075	+1.847	.006	.007	3	4
LUNG_NSCLC_LUSC	SAMD9 →	-3.845	-1.398	.007	<.001	3	4
BREAST	ADK →	-1.463	-1.678	.008	<.001	3	3
SOFT_TISSUE	ARSJ →	-3.440	-1.704	<.001	<.001	3	3
SOFT_TISSUE	ANLN →	-1.343	-1.704	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903365 vs PSPH — CNS

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