Protein localization to basolateral plasma membrane

Across TCGA patient cohorts, RNA activity of the Protein localization to basolateral plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RERG-AS1, SCN2B, and RPL15P13, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to basolateral plasma membrane activity versus RERG-AS1 in UCEC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RERG-AS1 →	+1.259	+0.149	.002	.006	3	5
GBM	SCN2B →	+0.739	+0.102	<.001	.003	3	4
GBM	RPL15P13 →	+0.100	+0.101	.007	.007	3	4
UCEC	RERG →	+1.482	+0.131	<.001	.009	3	4
HNSC	JAKMIP1 →	-0.165	-0.117	.005	.007	3	3
HNSC	EGR3 →	-0.726	-0.097	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903361 vs RERG-AS1 — UCEC

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