Protein localization to basolateral plasma membrane

Across TCGA cell cohorts, RNA activity of the Protein localization to basolateral plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF122, ETV1, and GNA12, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RNF122 grouped by Protein localization to basolateral plasma membrane-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RNF122 →	-1.328	-1.168	.008	.009	3	4
CNS	ETV1 →	-1.667	-1.025	.006	.003	3	4
SOFT_TISSUE	GNA12 →	+1.105	+1.555	.003	<.001	3	3
SOFT_TISSUE	RNF220 →	+0.759	+1.608	.008	<.001	3	3
BLOOD_Myeloma	LYRM4 →	-0.875	-1.640	.009	.007	3	3
BREAST	APEX2 →	-0.702	-0.711	.007	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RNF122 by Protein localization to basolateral plasma membrane activity — STOMACH

Explore this box plot interactively →