Regulation of Golgi organization

Across TCGA patient cohorts, RNA activity of the Regulation of Golgi organization pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CSRP1, EFEMP1, and EFEMP2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of Golgi organization activity versus CSRP1 in CCRCC (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CSRP1 →	+0.745	+0.033	<.001	<.001	3	7
CCRCC	EFEMP1 →	+0.726	+0.028	<.001	.001	3	7
CCRCC	EFEMP2 →	+0.722	+0.029	<.001	<.001	3	6
CCRCC	FRZB →	+0.714	+0.027	.001	.002	3	6
BRCA	PDLIM7 →	+0.606	+0.041	<.001	<.001	3	6
BRCA	PLXDC2 →	+0.588	+0.042	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903358 vs CSRP1 — CCRCC

Explore this scatter interactively →