Regulation of Golgi organization

Across TCGA patient cohorts, RNA activity of the Regulation of Golgi organization pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INSYN1, MYL12B, and CREG2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of Golgi organization activity versus INSYN1 in GBM (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	INSYN1 →	+0.961	+0.357	<.001	.006	3	4
LSCC	MYL12B →	+0.340	+0.339	<.001	.001	3	4
GBM	CREG2 →	+1.450	+0.388	<.001	.005	3	4
UCEC	GTF2IP4 →	+1.016	+0.444	<.001	.005	3	4
HNSC	P2RY1 →	+0.797	+0.517	.004	<.001	3	4
HNSC	LRRC8E →	+0.340	+0.574	.008	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903358 vs INSYN1 — GBM

Explore this scatter interactively →