Regulation of Golgi organization

Across TCGA cell cohorts, RNA activity of the Regulation of Golgi organization pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAPK1, NPIPB13, and GOLPH3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of Golgi organization activity versus MAPK1 in SKIN (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MAPK1 →	+1.034	+0.819	.005	.005	3	6
SKIN	NPIPB13 →	+0.773	+0.698	<.001	.004	3	4
LUNG_NSCLC_LUAD	GOLPH3 →	+0.930	+0.461	<.001	.006	3	4
KIDNEY	ZNF66 →	+1.233	+1.406	.006	.007	3	3
SOFT_TISSUE	SNAP29 →	+0.673	+1.072	<.001	.004	2	4
LIVER	SDF4 →	+1.190	+0.373	.001	.009	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903358 vs MAPK1 — SKIN

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