Response to dopamine

Across TCGA patient cohorts, RNA activity of the Response to dopamine pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLK, SRRM2, and VIRMA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to dopamine activity versus SLK in HNSC (Pearson r = 0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SLK →	+0.210	+0.031	.008	.006	3	6
LSCC	SRRM2 →	-0.169	-0.041	.005	<.001	3	6
UCEC	VIRMA →	-0.159	-0.041	.004	<.001	3	6
GBM	NELFCD →	-0.245	-0.046	<.001	.001	3	6
OV	PHF3_S1642 →	-0.650	-0.033	<.001	<.001	3	6
OV	PTCD3 →	-0.335	-0.026	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903350 vs SLK — HNSC

Explore this scatter interactively →