Response to dopamine

Across TCGA patient cohorts, RNA activity of the Response to dopamine pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CASC18, ACTA2, and SGIP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to dopamine activity versus CASC18 in LSCC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CASC18 →	+0.375	+0.268	<.001	<.001	3	8
OV	ACTA2 →	+1.688	+0.261	<.001	.001	3	7
CCRCC	SGIP1 →	+0.714	+0.218	.002	<.001	3	7
OV	CALD1 →	+1.138	+0.178	<.001	<.001	3	7
OV	TAGLN →	+1.264	+0.252	<.001	.002	3	7
CCRCC	LMOD1 →	+1.082	+0.220	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903350 vs CASC18 — LSCC

Explore this scatter interactively →