Response to dopamine

Across TCGA cell cohorts, RNA activity of the Response to dopamine pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAVIN1, COL5A1, and TGFB1I1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to dopamine activity versus CAVIN1 in LIVER (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CAVIN1 →	+2.659	+0.466	.002	.003	3	7
LIVER	COL5A1 →	+4.508	+0.435	.002	<.001	3	7
LIVER	TGFB1I1 →	+3.936	+0.415	.001	.005	3	7
OVARY	THBS1 →	+3.030	+0.318	.003	.002	3	6
LARGE_INTESTINE	CRIM1 →	+2.096	+0.306	.001	.001	2	7
LIVER	CCDC80 →	+4.117	+0.388	.003	.008	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903350 vs CAVIN1 — LIVER

Explore this scatter interactively →