Positive regulation of bicellular tight junction assembly

Across TCGA patient cohorts, RNA activity of the Positive regulation of bicellular tight junction assembly pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CENPC, PARN, and OR1L8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of bicellular tight junction assembly activity versus CENPC in UCEC (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CENPC →	-0.346	-0.453	<.001	.001	3	4
UCEC	PARN →	-0.263	-0.451	.007	.009	3	4
OV	OR1L8 →	-0.145	-0.477	.005	.003	3	3
LUAD	MIR6762 →	+0.643	+0.497	<.001	.001	3	3
CCRCC	RNA5SP483 →	-0.519	-0.292	.001	.005	3	3
HNSC	TAS2R3 →	-0.596	-0.560	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903348 vs CENPC — UCEC

Explore this scatter interactively →