Positive regulation of bicellular tight junction assembly

Across TCGA cell cohorts, RNA activity of the Positive regulation of bicellular tight junction assembly pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLDN16, CLDN1, and ADGRF1, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of bicellular tight junction assembly activity versus CLDN16 in OVARY (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CLDN16 →	+2.381	+0.145	.001	.001	3	14
LIVER	CLDN1 →	+4.540	+0.333	<.001	<.001	3	12
OESOPHAGUS	ADGRF1 →	+3.748	+0.236	<.001	.002	3	12
STOMACH	EPHA2 →	+2.440	+0.244	.001	<.001	3	12
LARGE_INTESTINE	AREG →	+2.263	+0.205	.001	<.001	3	11
LARGE_INTESTINE	BIRC3 →	+2.343	+0.228	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903348 vs CLDN16 — OVARY

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