Positive regulation of bicellular tight junction assembly

Across TCGA cell cohorts, RNA activity of the Positive regulation of bicellular tight junction assembly pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NKIRAS1, MTPAP, and EPC1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of bicellular tight junction assembly activity versus NKIRAS1 in STOMACH (Pearson r = -0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	NKIRAS1 →	-0.907	-0.548	.001	<.001	3	3
PANCREAS	MTPAP →	-0.699	-0.257	.005	.008	3	2
PANCREAS	EPC1 →	-0.981	-0.288	<.001	.005	3	2
OESOPHAGUS	GPRIN1 →	-1.096	-0.262	.003	.005	3	2
LUNG_NSCLC_LUAD	ISG20L2 →	-0.592	-0.243	.009	.005	2	3
LUNG_NSCLC_LUAD	PNP →	-0.998	-0.289	.005	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903348 vs NKIRAS1 — STOMACH

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